Identification of both GABAA receptors and voltage-activated Na+ channels as molecular targets of anticonvulsant α-asarone
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چکیده
منابع مشابه
Identification of both GABAA receptors and voltage-activated Na+ channels as molecular targets of anticonvulsant α-asarone
Alpha (α)-asarone, a major effective component isolated from the Chinese medicinal herb Acorus tatarinowii, is clinically used as medication for treating epilepsy, cough, bronchitis, and asthma. In the present study, we demonstrated that α-asarone targets central nervous system GABAA receptor as well as voltage-gated Na(+) channels. Using whole-cell patch-clamp recording, α-asarone inhibited sp...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2014
ISSN: 1663-9812
DOI: 10.3389/fphar.2014.00040